| Pharmacy Drug Brand Name: | Actos® |
| Active Ingredient(s): | pioglitazone |
| Strength(s) / Dose(s): | 15 mg, 30 mg, and 45 mg |
| Delivery / Dosage Form(s): | Tablets |
| Company Manufacturer Name: | Takeda Chemical Industries, Ltd. |
| Availability / Prescription: | Prescription only |
| FDA Approval Date *: | July 15, 1999 |
* Approval by the FDA does not necessarily mean that this drug is available for consumers at this time.
What is Actos used for?
Actos, in addition to diet and exercise, improves blood sugar control in patients with type 2 diabetes (non-insulin dependent diabetes). Actos can be used alone or in combination with a sulfonylurea, metformin, or insulin when diet, exercise, and one of these agents or diet, exercise, plus Actos alone are not are not enough to control blood sugar.
Who should not take Actos?
- Do not take Actos for Type 1 diabetes (juvenile diabetes) or diabetic ketoacidosis.
- If you have heart failure, fluid retention or active liver disease or damage your health care (healthcare) provider will evaluate you to decide if Actos is right for you.
General Precautions with Actos:
- In drug testing, Actos did not cause liver toxicity or an increase in liver enzymes. However, Actos is in the same class of drugs as Rezulin, which has been associated with rare but serious liver injury, including liver failure leading to transplant or death.
- Because the liver safety profile of Actos is not fully determined yet, your doctor will do blood tests that evaluate your liver before starting you on Actos. These blood tests should be repeated every two months for the first year, then regularly after that.
- Call your health care (healthcare) provider right away if you develop nausea, vomiting, stomach pain or discomfort, a feeling of tiredness, or having no energy, loss of appetite, dark urine, or jaundice (yellow coloring of eyes and skin). These may be the symptoms of liver problems.
- When taking Actos with insulin or certain other oral diabetes medicines, there is a risk of your blood sugar becoming dangerously low. Ask your health care (healthcare) provider about symptoms of low blood sugar, conditions that make low blood sugar more likely, and what to do if you get it. Make sure to explain to family members.
- If you are a woman who has not reached menopause but have not had menstrual periods; you may become pregnant unless you use an effective method of birth control. Actos, like other drugs in this class, may cause insulin resistant women to start ovulating again.
- Women should tell their doctor if they notice any changes in their monthly menstrual cycle.
- During periods of stress on the body, such as fever, trauma, infection, or surgery, your medication requirements may change; contact your health care (healthcare) provider promptly.
What should I tell my doctor or health care (healthcare) provider?
Women taking oral birth control pills should talk to their health care (healthcare) provider when taking Actos, because the effectiveness of oral birth control pills can be reduced.
Tell your health care (healthcare) provider if you are trying to become pregnant, are already pregnant, or are breast-feeding.
Because certain other medications may interact with Actos, review all medications that you are taking with your health care (healthcare) provider, including those that you take without a prescription.
What are some possible side effects of Actos? <(This is not a comprehensive list of possible side effects reported with Actos. Your doctor or pharmacist can provide expert advice on the possible side effects of this drug.)
- Cough or cold
- Headache
- Inflammation of the sinuses or throat
- Muscle pain or discomfort
- Swelling or fluid retention